Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study
Identifieur interne : 000143 ( France/Analysis ); précédent : 000142; suivant : 000144Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: a 2-year multicentre, comparative, prospective cohort study
Auteurs : Andreas Vychytil [Autriche] ; Csar Remn [Espagne] ; Catherine Michel [France] ; Paul Williams [Royaume-Uni] ; Ana Rodrguez-Carmona [Espagne] ; Beln Marrn [Belgique] ; Ed Vonesh [Belgique] ; Synke Van Der Heyden [Belgique] ; Jose C. Divino Filho [Belgique]Source :
- Nephrology Dialysis Transplantation [ 0931-0509 ] ; 2008-11.
Abstract
Background. Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associated with icodextrin have been reported. Methods. The primary objective of this multicentre, longitudinal, observational, non-interventional, prospective cohort study, which included 722 PD patients, was to evaluate the incidence of overall peritonitis in patients treated with icodextrin-containing PD solutions (Extraneal) used during one long-dwell exchangeday compared with those treated with non-icodextrin-containing PD solutions. The secondary objective was to determine if culture-negative peritonitis rates differed between patients treated with icodextrin from two independent manufacturers. All peritonitis episodes were assessed by a Steering Committee in a blind manner. Results. There was no significant difference between icodextrin-treated and control patients in the adjusted overall, culture-positive or culture-negative peritonitis rates. When stratified by the icodextrin supplier, there was no significant difference in the adjusted rate of culture-negative peritonitis episodes between groups. Conclusion. Subjects receiving icodextrin as part of their PD regimen experienced neither a higher rate of culture-negative peritonitis nor a lower rate of infectious peritonitis compared with non-icodextrin users. There was no significant influence of the icodextrin raw material supplier on peritonitis rates.
Url:
DOI: 10.1093/ndt/gfn322
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Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associated with icodextrin have been reported. Methods. The primary objective of this multicentre, longitudinal, observational, non-interventional, prospective cohort study, which included 722 PD patients, was to evaluate the incidence of overall peritonitis in patients treated with icodextrin-containing PD solutions (Extraneal) used during one long-dwell exchangeday compared with those treated with non-icodextrin-containing PD solutions. The secondary objective was to determine if culture-negative peritonitis rates differed between patients treated with icodextrin from two independent manufacturers. All peritonitis episodes were assessed by a Steering Committee in a blind manner. Results. There was no significant difference between icodextrin-treated and control patients in the adjusted overall, culture-positive or culture-negative peritonitis rates. When stratified by the icodextrin supplier, there was no significant difference in the adjusted rate of culture-negative peritonitis episodes between groups. Conclusion. Subjects receiving icodextrin as part of their PD regimen experienced neither a higher rate of culture-negative peritonitis nor a lower rate of infectious peritonitis compared with non-icodextrin users. There was no significant influence of the icodextrin raw material supplier on peritonitis rates.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Paris</li></settlement></list><tree><country name="Autriche"><noRegion><name sortKey="Vychytil, Andreas" sort="Vychytil, Andreas" uniqKey="Vychytil A" first="Andreas" last="Vychytil">Andreas Vychytil</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Remn, Csar" sort="Remn, Csar" uniqKey="Remn C" first="Csar" last="Remn">Csar Remn</name></noRegion><name sortKey="Rodrguez Carmona, Ana" sort="Rodrguez Carmona, Ana" uniqKey="Rodrguez Carmona A" first="Ana" last="Rodrguez-Carmona">Ana Rodrguez-Carmona</name></country><country name="France"><noRegion><name sortKey="Michel, Catherine" sort="Michel, Catherine" uniqKey="Michel C" first="Catherine" last="Michel">Catherine Michel</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Williams, Paul" sort="Williams, Paul" uniqKey="Williams P" first="Paul" last="Williams">Paul Williams</name></noRegion></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Marrn, Beln" sort="Marrn, Beln" uniqKey="Marrn B" first="Beln" last="Marrn">Beln Marrn</name></region><name sortKey="Filho, Jose C Divino" sort="Filho, Jose C Divino" uniqKey="Filho J" first="Jose C. Divino" last="Filho">Jose C. Divino Filho</name><name sortKey="Van Der Heyden, Synke" sort="Van Der Heyden, Synke" uniqKey="Van Der Heyden S" first="Synke" last="Van Der Heyden">Synke Van Der Heyden</name><name sortKey="Vonesh, Ed" sort="Vonesh, Ed" uniqKey="Vonesh E" first="Ed" last="Vonesh">Ed Vonesh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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